Personally I do not advise anyone to take a large dose of psychedelics. I think a low dose of ayahuasca can be much more beneficial, combined with metta meditation or therapy. Especially NMT ayahuasca, or vaping whole rue seeds until rue-drunk and then vaping DMT if one does not have the time for oral NMT ayahuasca. There are some alkaloids that are present in whole rue seeds (but not rue extracts) which seem to produce a much more healing and magical experience at low doses of vaped DMT.
Keep some dimethylsulfoxide on hand at all times, because it can instantly turn a bad trip good, and it can reverse brain damage from an overdose of any toxic drug. I suggest taking 5 to 15 mL of DMSO every hour until one feels better, but likely only one dose is required.
Having said that all, here is the collective wisdom from the net if you are going to try a large psychedelic dose for some reason...
Chat and find lots of factsheets and combination guidance at tripsit.me/
Free tripsitting hotline at The Fireside Project as well as ICEERS.org
The Hopkins/Griffiths protocol for psilocybin (enduring benefits), summarized by GordoTek: https://www.patreon.com/posts/28680845
Two manuals at: zendoproject.org/education/
“*The ZENDO Project Training Manual*” especially Appendix A: “How to Work With Difficult Psychedelic Experiences” (pages 13 - 17)
“*The Manual of Psychedelic Support*” …. 328 pages
“A comprehensive guide to setting up and running compassionate care services for people having difficult drug experiences at music festivals and similar events.”
“*How to Work with Difficult Psychedelic Experiences*” Video http://youtu.be/1aBjoARwlOY
“*A Method of Conducting Therapeutic Sessions with MDMA*” George R. Greer, M.D. & Requa Tolbert, M.S.N. Journal of Psychoactive Drugs Volume 30 (4), October – December 1998 pages 371 – 379) 10 pages
“As much as possible, everything done or said in preparing clients to take this compound attempted to give this message”:
“You are consciously taking a medicine to open yourself to whatever teachings you may need at this time. Neither you nor we know what these teachings will be or how they may occur. We will provide a safe place for your explorations, and will be available to assist you with any difficulties; but all you learn that is real comes from within you – not from us, or from the medicine itself.”